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(The curves are a simpli?cation of the idealsituation with a number of assumptions – see ? g-ure legend – but they do illustrate the physiol-ogy). White’s blood pressure to be low be-cause of fluid loss.

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Retinal pigment epithelium (RPE), the outermost layer ofthe retina2.

The mostinteresting aspect of this resistance to death by Tregs in aged individuals is the fact thatinstead of Tregs depending on dwindling supplies of IL-2 as we age, these cells make use ofanother gamma-chain lymphokine called IL-15.

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